一项关于多粘菌素 B 硫酸盐-杆菌肽锌-新霉素硫酸盐与简单纱布敷料在皮肤磨削伤口中的随机研究评估了每种治疗对疤痕的影响 。70 名受试者的上背部有三个均匀的皮肤磨削伤口，分别用三重抗生素软膏（多粘菌素 B-杆菌肽-新霉素）、双重抗生素（多粘菌素 B-杆菌肽）或简单的非封闭性纱布敷料同时治疗 ，每天两次 ，最多 14 天 。在皮肤磨削后 45 天和 90 天，将皮肤表面测试部位愈合后出现的色素变化和纹理变化（疤痕）与相邻的正常皮肤进行比较。利用荧光灯 、长波紫外线和临床彩色摄影对这些变化进行目视分级 。三重抗生素软膏在减少磨皮伤口疤痕方面优于单纯使用纱布敷料 。这种新软膏的好处在对色素变化的影响方面更为明显。（Cutis. 2000 Jun;65(6):401-4）
A Newly Formulated Topical Triple-Antibiotic Ointment Minimizes Scarring
A randomized study of polymyxin B sulfate-bacitracin zinc-neomycin sulfate versus simple gauzetype dressings in dermabrasion wounds assessed the effects that each treatment had on scarring. Each of three uniform dermabrasion wounds created on the upper backs of 70 subjects was treated concurrently with a triple-antibiotic ointment (polymyxin B-bacitracin-neomycin), a double antibiotic (polymyxin B-bacitracin), or a simple, non-occlusive, gauze-type dressing, twice daily for up to 14 days. Pigmentary changes and textural changes (scarring) appearing after healing at the skin surface test sites were compared to adjacent normal skin at 45 and 90 days post-dermabrasion. These changes were graded visually utilizing fluorescent light, long-wave ultraviolet light, and by clinical color photography. The triple-antibiotic ointment was superior to simple gauze-type dressing alone in minimizing the scarring observed in dermabrasion wounds. The benefit of this new ointment was more pronounced in its effect on pigmentary changes. （Cutis. 2000 Jun;65(6):401-4）